Prpf8 increases the aggressiveness of hepatocellular carcinoma by regulating fak/akt pathway via fibronectin 1 splicing

HIGHLIGHTS

• who: Juan L. Lu00f3pez-Cu00e1novas from the cell death and modulates cell differentiation and polarity, and PRPF8-mediated hyperplastic growth is induced by different oncogenes Indeed, seems to be crucial for appropriate constitutive and alternative mRNA splicing11. , mutations have been associated with severe forms of retinitis pigmentosa as well as with the initiation of various types of myeloid neoplasms and with decreased survival in patients with leukemia12. In solid tumors, silencing of , was found to result in cancer subtypespecific implications in breast cancer cell lines13, while in prostate cancer, is involved in androgen receptor splicing14. In addition . . .
  

   

  

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