Prss2 remodels the tumor microenvironment via repression of tsp1 to stimulate tumor growth and progression

HIGHLIGHTS

• who: Lufei Sui from the (median follow-up time of survivors, months have published the research work: PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression, in the Journal: (JOURNAL) of 11/06/2021
• what: The authors demonstrate that PRSS2 represses Tsp-1, not via its enzymatic activity, but by binding to low-density lipoprotein receptor-related protein 1 (LRP1). The authors demonstrate that treatment of WI38 cells with JNK inhibitor results in a 2.5-fold decrease in Tsp-1 expression in fibroblasts (1 vs 0.4, n . . .
  

   

  

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