HIGHLIGHTS
- who: Mustapha Si-Tahar from the Institut Pasteur, France University of Pittsburgh, United States have published the Article: Pseudomonas aeruginosa Lipoxygenase LoxA Contributes to Lung Infection by Altering the Host Immune Lipid Signaling, in the Journal: (JOURNAL)
- what: The authors show that clinical isolates of P. aeruginosa do secrete a functional lipoxygenase. The authors show that LoxA confers a survival advantage as it reduces P. aeruginosa clearance in lung tissues in the mouse model settings. Similar findings were obtained when the authors focused on macrophages and CD86, a co-stimulatory molecule known to be critical . . .
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