HIGHLIGHTS
- who: R. from the Department of Biochemistry, University of Illinois Urbana-Champaign, Urbana, IL, USA, Department of have published the research: PTBP1 controls intestinal epithelial regeneration through post-transcriptional regulation of gene expression, in the Journal: (JOURNAL)
- what: The authors report here that depletion of an RNA-binding protein named polypyrimidine tract binding protein 1 (PTBP1) in mouse intestinal epithelial_cells causes intestinal stem_cell death and epithelial regeneration failure. Mechanistically, the authors show that PTBP1 inhibits neuronal-like splicing programs in intestinal crypt cells, which is critical for maintaining intestinal stem_cell stemness. The authors show that . . .
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