Ptchd1 binds cholesterol but not sonic hedgehog, suggesting a distinct cellular function

HIGHLIGHTS

  • who: Mimmu K. Hiltunen and collaborators from the Faculty of Biological and Environmental Sciences, University of Helsinki, Helsinki, Finland have published the research: PTCHD1 Binds Cholesterol but Not Sonic Hedgehog, Suggesting a Distinct Cellular Function, in the Journal: (JOURNAL) of 12/07/2022
  • what: The analysis showed that six of them (ATXN2L, DDX3X, DDX6, G3BP2, NUFIP2, and PABP1) form a network of experimentally determined physical Int. The authors report for the first time the purification to homogeneity of PTCHD1, Due to the lack of charge-neutralising residues in both, and NPC1 being known to transport . . .

     

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