HIGHLIGHTS
SUMMARY
Immune suppression may also confer an increased risk of PTCL, NOS, possibly including those derived from cytotoxic T_cells, and a history of prior immunosuppressive therapies has been reported in 3.8% of PTCL, NOS patients. With the possible exception of PTLD, EBV more commonly affects B-cells within the tumor microenvironment, and rarely infects malignant T_cells, at least in the West. T-cell lymphomas derived from gd T_cells classically involve specific extranodal sites, but when classified as PTCL, NOS, transcriptionally resemble extranodal NK/T_cell lymphomas. T-cell receptor signaling plays an important role in . . .
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