HIGHLIGHTS
- who: Ludovica Ciuffreda from the Division, Rome, Italy University of have published the article: PTEN: multiple functions in human malignant tumors, in the Journal: (JOURNAL)
SUMMARY
PTEN stands for Phosphatase and TENsin homolog deleted on chromosome 10 and is a classical tumor suppressor gene located in the 10q23 region of chromosome 10 encoding for a 403-aminoacid multifunctional protein (predicted MW 47 kDa), which possesses lipid and protein phosphatase activities. PTEN was identified in 1977 by three independent groups: two groups used a positionalcloning approach, whereas the third group identified PTEN by a . . .
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