Purine nucleoside phosphorylase deficiency induces p53-mediated intrinsic apoptosis in human induced pluripotent stem cell-derived neurons

HIGHLIGHTS

• who: Michael Tsui from the The University have published the article: Purine nucleoside phosphorylase deficiency induces p53-mediated intrinsic apoptosis in human induced pluripotent stem cell-derived neurons, in the Journal: Scientific Reports Scientific Reports

SUMMARY

In P ­ NP-/- cells, the ­R2 between p53 and cleaved casp-9 was much greater (p and amp;lt; 0.001, ­R2=0.5154) in comparison to PNP-proficient cells (p and amp;lt; 0.001, ­R2=0.0496) (Fig 4G), suggesting that the cleaved casp-9 expression might be linked to p53 expression in PNP-deficient . . .

 



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