HIGHLIGHTS
- who: Stephanie Link from the University Munich, Planegg-Martinsried, Germany have published the Article: PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: Using quantitative in_vitro binding assays, here the authors show that PWWP2A is able to directly interact with at least five different chromatin moieties with its distinct domains. The authors demonstrate that the P1_P2 region of PWWP2A specifically requires binding to the MTA1 isoform for recruitment of the entire MHR complex (M1HR). The authors propose that PWWP2A recruits HDACs in . . .
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