Pyrazinamide triggers degradation of its target aspartate decarboxylase

HIGHLIGHTS

• who: Pooja Gopal from the Lin School National University have published the article: Pyrazinamide triggers degradation of its target aspartate decarboxylase, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
• what: The authors show here that POA, the bioactive component of PZA, blocks mycobacterial CoA biosynthesis by promoting degradation of its target PanD by the caseinolytic protease ClpC1-ClpP.

SUMMARY

In vitro and in_vivo screening to isolate spontaneous POA-resistant Mtb mutants identified missense mutations in either panD or the unfoldase clpC1, encoding a component of the caseinolytic protease ClpC1-ClpP3,5-8 . . .

 



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