HIGHLIGHTS
- who: Boris S. Zhorov and Ke Dong from the Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON L S , Canada have published the research work: Pyrethroids in an AlphaFold2 Model of the Insect Sodium Channel, in the Journal: (JOURNAL)
- what: The authors propose that respective kdr mutations would allosterically affect the geometry of the PyR1 and/or PyR2 sites and hence, the affinity of the ligands. Such analysis is beyond the goals of this study. Molecular dynamics simulations and molecular modeling with Monte Carlo energy minimizations, which employ high-resolution crystal or cryo . . .
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