Pyroglutamate amyloid-β (aβ): a hatchet man in alzheimer disease*

HIGHLIGHTS

• who: Sadim Jawhar from the Sadim Jawhar, Oliver Wirths, and Thomas ABayer, From the Department of Molecular Psychiatry, Georg-August-University Gu00f6ttingen, University Medicine Gu00f6ttingen, Gu00f6ttingen, Germany have published the paper: Pyroglutamate Amyloid-u03b2 (Au03b2): A Hatchet Man in Alzheimer Disease*, in the Journal: (JOURNAL) of November/11,/2011

SUMMARY

Transgenic mice that produce high levels of A␤pE3- 42 show severe neuron loss. A␤1- 43 has been discussed as a novel toxic peptide in AD. Biochemical studies showed that A␤ peptides isolated from AD brains were post-translationally modified by isomerization . . .

 



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