HIGHLIGHTS
- who: Yuan Tan from the Medical Sciences (SGPGI), India Hubei University of Medicine, China have published the research: Pyroptosis-triggered pathogenesis: New insights on antiphospholipid syndrome, in the Journal: (JOURNAL)
SUMMARY
APS (antiphospholipid syndrome) is considered as a systemic autoimmune disease accompanied with inflammatory response, venous or arterial vascular thrombosis, recurrent fetal loss, and early pregnancy loss or pregnancy morbidity. In mouse macrophages, caspase-8 functions as a regulator of pyroptosis, also contributing to GSDMD pores formation and pyroptotic cell death. GzmB has been identified to activate caspase-3, then caspase-3 cleaves . . .
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