Pyroptotic patterns in blood leukocytes predict disease severity and outcome in covid-19 patients

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SUMMARY

    In the Frontiers in Immunology | www.frontiersin.org July 2022 | Volume 13 | Article 888661 Pyroptotic Patterns in COVID-19 development of severe COVID-19 disease, uncontrolled systemic hyperinflammation caused by a dysregulated immune_response leads to the release of pro-inflammatory cytokines and chemokines, a condition that is known as cytokine storm. On the one hand, SARS-CoV-2 nucleocapsid can prevent Gasdermin D cleavage, thus reducing host pyroptosis and suppressing the immune_response, in addition to inhibiting coronavirus infection by promoting non-classical secretion of b-interferon. Based on transcriptome data of patients with or . . .

     

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