HIGHLIGHTS
SUMMARY
Some trials of treatments for COVID-19 used PRO measures that had been validated for use in other medical conditions with similar symptoms to COVID-19, such as the Influenza Patient-Reported Outcome (FLU-PRO), which was developed for assessment of influenza symptoms. The newly developed PRO, called the ACTIV-2 COVID-19 Symptom Diary (ACSD), was developed by the clinical trial team as a daily diary to assess COVID-19 symptom severity. Includes: o Three global items o Fourteen symptom items with response opons on a 4-point scale o Two symptom items . . .
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