Quantification of mutant spop proteins in prostate cancer using mass spectrometry-based targeted proteomics

HIGHLIGHTS

• who: Hui Wang from the Abbreviations SPOP: speckle-type POZ protein have published the paper: Quantification of mutant SPOP proteins in prostate cancer using mass spectrometry-based targeted proteomics, in the Journal: (JOURNAL)
• what: In this report the authors demonstrate that a highly sensitive targeted proteomic method, PRISM-SRM (high-pressure, high-resolution separations coupled with intelligent selection and multiplexing-selected reaction monitoring), is capable of providing quantitative information on both wild-type (WT) SPOP and four distinct single amino_acid variants of SPOP that have been implicated in prostate cancer. The authors reason that the . . .
  

   

  

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