Quantification of nanoscale dose enhancement in gold nanoparticle-aided external photon beam radiotherapy

HIGHLIGHTS

SUMMARY

    While Monte Carlo (MC) studies report controversial results concerning dose enhancement attributed to AuNPs presence in a target irradiated by photons in the MV region, a substantial radiosensitivity enhancement is described in_vivo and in_vitro. Beam quality, AuNPs concentration and their physicochemical characteristics, the method of AuNPs administration and the type of cell line investigated are only some of the parameters that appear to influence dose enhancement in published in_vivo and in_vitro studies. The discrepancies between in silico and in_vitro/in_vivo experiments complicate the implementation of AuNPs in clinical EBRT and underline the need for . . .

     

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