Quantifying cooperative multisite binding in the hub protein lc8 through bayesian inference

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  • who: Aidan B. Estelle et al. from the Department of Biochemistry and Biophysics, Oregon State University, Corvallis, Oregon, United States of have published the paper: Quantifying cooperative multisite binding in the hub protein LC8 through Bayesian inference, in the Journal: (JOURNAL) of April/21,/2023
  • what: The authors primarily examine the essential hub protein LC8 a small dimer that binds disordered regions of 100+ client proteins in two symmetrical grooves at the dimer interface. The authors propose that cooperativity in the LC8 system drives the formation of saturated induced-dimer structures the functional units of . . .

     

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