Quantifying evolutionary constraints on b-cell affinity maturation

HIGHLIGHTS

• who: Frederick A. Matsen IV and colleagues from the Seattle, WA, USA Departments of Statistics and Biology, University of Washington, Seattle, WA, USA have published the research: Quantifying evolutionary constraints on B-cell affinity maturation, in the Journal: (JOURNAL) of 31/08/2022
• what: The authors develop modern statistical molecular evolution methods for the analysis of high-throughput B-cell sequence data, and then apply them to a very deep short-read dataset of BCRs. Next, the authors investigate how substitution processes vary between V genes and find that the primary source of variation is . . .
  

   

  

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