HIGHLIGHTS
SUMMARY
The authors measure the affinities of 65,000 interactions involving PDZ domains and their target PDZ-binding motifs (PBM) within a human interactome region particularly relevant for viral infection and cancer. The authors measured with unprecedented coverage and sensitivity ~65,000 PDZ-PBM affinities in a defined region of the human interactome targeted by viral PBMs, including those of oncogenic proteins HPV E6 and HTLV1 Tax1. The authors also show that amounts of prey proteins captured in cell lysates by exogenous PDZ or PBM baits correlate with the corresponding PDZ-PBM affinities. To quantify . . .
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