HIGHLIGHTS
SUMMARY
Colorectal cancer (CRC) is a major public health and socio-economic problem. About twenty percent of CRC patients already have metastases at diagnosis, and metastatic CRC (mCRC) is mostly an incurable disease. Under physiological conditions, due to the plasticity of their charge distribution, polyamines bind several negatively charged molecules, including nucleic_acids, ATP, proteins, and acid phospholipids, and perform critical biological functions, such as DNA stabilization, nucleic_acid and protein synthesis, gene regulation, cell growth, proliferation, differentiation, migration, development, and immunological responses. Changes in the profile of polyamines in urine can discriminate CRC patients from healthy . . .
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