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- who: Benedikt Frieg from the Institute National University of Sydney, Sydney, NSW, Australia have published the paper: Quaternary structure of patient-homogenate amplified u03b1-synuclein fibrils modulates seeding of endogenous u03b1-synuclein, in the Journal: (JOURNAL) of 12/06/2022
- what: The experiments show that MSAPMCA fibrils display higher potency in seeding the endogenous oligodendroglial u03b1Syn and promoting the redistribution of the oligodendroglial-specific phosphoprotein TPPP/p25u03b1 from the myelin sheath to the cell soma as compared to PD-PMCA fibrils (Fig 1). The authors note however that although the MSA-PMCA structure determined in . . .
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