Quinate-based ligands for irreversible inactivation of the bacterial virulence factor dhq1 enzyme — a molecular insight

HIGHLIGHTS

• who: . and colleagues from the University of Verona, Italy have published the research work: Quinate-based ligands for irreversible inactivation of the bacterial virulence factor DHQ1 enzyme u2014 A molecular insight, in the Journal: (JOURNAL)
• what: The results of this study show that replacement of the C3 hydroxy group of_(-)-quinic acid by a hydroxyamino substituent (compound 6) results in a time-dependent irreversible inhibitor, whereas compound 7, in which the latter functionality is replaced by an amino group, does not allow covalent modification of the enzyme.
• how: For the St-DHQ1/6 . . .
  

   

  

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