HIGHLIGHTS
- who: LDH and colleagues from the Collegeville, PA, USA have published the Article: Quinoline 3-sulfonamides inhibit lactate dehydrogenase A and reverse aerobic glycolysis in cancer cells, in the Journal: (JOURNAL)
- what: The aim of this study was to identify and characterize potent and selective inhibitors of LDHA. The authors report here discovery and development of quinoline 3sulfonamides that inhibit LDHA enzyme with single-digit nanomolar potency.
SUMMARY
Reduction of LDHA levels in cancer cells by siRNA or shRNA stimulates mitochondrial respiration and reduces cellular proliferative and tumorigenic potential both in_vitro . . .
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