Rad18 opposes transcription-associated genome instability through fancd2 recruitment

HIGHLIGHTS

• who: James P. Wells and collaborators from the Terry Fox Laboratory, BC Cancer, Vancouver, Canada, University of British Columbia, Department of have published the article: RAD18 opposes transcription-associated genome instability through FANCD2 recruitment, in the Journal: (JOURNAL) of June/23,/2022
• what: The authors show that deficient cells have higher levels of transcriptionreplication conflicts and accumulate DNA:RNA hybrids that induce DNA double strand breaks and replication stress. This work provides new insight to how the FANCD2 protein is brought to potentially damaging sites in the genomes . / __NEWPAGE__PLOS design data collection and analysis decision . . .
  

   

  

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