HIGHLIGHTS
- who: Yijiang Xu from the University of have published the research: Rad52 mediates class-switch DNA recombination to IgD, in the Journal: NATURE COMMUNICATIONS NATURE COMMUNICATIONS
- what: By activating Rad52-/- mouse B cells and RAD52 siRNA knockdown human B cells with different stimuli together with molecular genetic methods, here the authors show that Rad52 critically effects Sμ-σδ DNA recombination and CSR to IgD, through a microhomology-mediated (MM) A-EJ process which is associated with junctional Sμ-σδ somatic point-mutations.
- how: The authors analyzed Rad52 Ku70 Ku86 and Aicda transcripts as well as . . .
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