HIGHLIGHTS
SUMMARY
The authors revealed that radiation remarkably induces IRAK1 expression and IRAK1 inhibition sensitizes glioma cells to radiation both in_vitro and in_vivo. Beads were sufficiently washed with lysis buffer and boiled in SDS loading buffer for detecting the bound protein in_vitro using western blotting assay. Overexpression of PRDX1 reverses the radiosensitivity resulting from IRAK1 depletion in_vitro To validate whether knockdown of IRAK1 downregulates PRDX1 and thus exerts a radiosensitive effect, the authors performed a series of rescue experiments. Taken together, these results suggested that IRAK1 promotes the radioresistance of glioma cells by PRDX1-mediated suppression . . .
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