Rapamycin alleviates protein aggregates, reduces neuroinflammation, and rescues demyelination in globoid cell leukodystrophy

HIGHLIGHTS

• who: Dar-Shong Lin and collaborators from the Department of Pediatrics, MacKay Memorial Hospital, Taipei, Taiwan have published the research work: Rapamycin Alleviates Protein Aggregates, Reduces Neuroinflammation, and Rescues Demyelination in Globoid Cell Leukodystrophy, in the Journal: Cells 2023, 12, x FOR PEER REVIEW of /2023/
• what: The authors determine the therapeutic effect of rapamycin in twitcher mice, the murine model of GLD, and report a reduction of protein aggregates, alleviation of neuroinflammation and demyelination, preservation of myelin integrity, and prolongation of lifespan.
• how: The authors investigated the therapeutic efficacy of the mTOR . . .
  

   

  

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