Rapamycin inhibits hepatitis b virus covalently closed circular dna transcription by enhancing the ubiquitination of hbx

HIGHLIGHTS

  • who: Ji-Hua Ren and Zhen-Zhen Zhang from the Institut National de la Santé et de la Recherche Médicale (INSERM), France Wuhan University, China have published the paper: Rapamycin inhibits hepatitis B virus covalently closed circular DNA transcription by enhancing the ubiquitination of HBx, in the Journal: (JOURNAL)
  • how: R For HBV cccDNA extraction the authors used the previously described modified Hirt method (Cheng et_al 2021). These results indicated that the ubiquitination level of HBx increased significantly after rapamycin treatment. These data showed that rapamycin A complete cure of HBV is still the . . .

     

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