HIGHLIGHTS
- who: Lin Hu from the of Biological and Medical Sciences, Soochow University, Ren'ai Road, Suzhou, Jiangsu, China have published the paper: Rapamycin recruits SIRT2 for FKBP12 deacetylation during mTOR activity modulation in innate immunity, in the Journal: (JOURNAL) of November/19,/2021
- what: The authors provide evidence that mTOR can promote antiviral response by inducing IRF3 serine phosphorylation, whereas rapamycin blocks mTOR activity in the antiviral response via SIRT2 recruitment and SIRT2-mediated FKBP12 deacetylation. Limitations of the study This study demonstrated that mTORC1 activity relies on FKBP12 acetylation and deacetylation status in response . . .
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