Rapamycin rescues mitochondrial dysfunction in cells carrying the m.8344a > g mutation in the mitochondrial trna

HIGHLIGHTS

• who: Mariantonietta Capristo from the Neurogenetica, via Altura, Italy have published the article: Rapamycin rescues mitochondrial dysfunction in cells carrying the m.8344Au2009>u2009G mutation in the mitochondrial tRNA, in the Journal: (JOURNAL)
• what: In_vitro correction of defective tRNA aminoacylation by the Cterm of human mt-leucyl tRNA synthetase has shown to be effective also for the classical MERRF mutation (Perli et_al 2016, 2020), as well as molecular approaches aimed at heteroplasmy shifting (Hashimoto et_al 2015; Gammage et_al 2016). The study provides novel information on the potential use of rapamycin as beneficial therapy for MERRF . . .
  

   

  

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