Rasa2 ablation in t cells boosts antigen sensitivity and long-term function

HIGHLIGHTS

• who: Julia Carnevale from the (UNIVERSITY) have published the Article: RASA2 ablation in T cells boosts antigen sensitivity and long-term function, in the Journal: (JOURNAL) of 31/07/2021
• what: To model intrinsic checkpoint signals, the authors focused on inhibitors of calcium and calcineurin signaling (tacrolimus and cyclosporine), which is a critical pathway for T_cell activation that is frequently suppressed in tumour-infiltrating T_cells16. Having observed that RASA2 ablation also promotes T_cell proliferative capacity under multiple immunosuppressive environments, the authors focused the subsequent efforts on characterizing the effects of RASA2 ablation in preclinical models . . .
  

   

  

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