Rat hepatocytes mitigate cadmium toxicity by forming annular gap junctions and degrading them via endosome-lysosome pathway

HIGHLIGHTS

• who: Junzhao Yuan et al. from the College of Veterinary Medicine, Yangzhou University, Wenhui East Road, Yangzhou, China have published the research: Rat Hepatocytes Mitigate Cadmium Toxicity by Forming Annular Gap Junctions and Degrading Them via Endosome-Lysosome Pathway, in the Journal: (JOURNAL)
• what: Although the experiments demonstrated that Cx43 internalization within 12 h was protective against Cd toxicity, intense Cx43 internalization, especially when cells formed AGJ to internalize and degrade Cx43 on a large scale, was temporary in saving Cd-induced single-cell death. These AGJs can be degraded by endosome-lysosomes, which is . . .
  

   

  

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