HIGHLIGHTS
- who: Ruian Ke and colleagues from the Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles have published the article: Rational Design and Adaptive Management of Combination Therapies for Hepatitis C Virus Infection, in the Journal: (JOURNAL) of June/30,/2015
- what: The authors develop a general model incorporating viral dynamics and pharmacokinetics/ pharmacodynamics to assess how suboptimal adherence affects resistance development and clinical outcomes. Using data from large-scale resistance assays the authors demonstrate that the risk of resistance can be reduced substantially by applying these principles to a combination . . .
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