Rational design and lead optimisation of potent antimalarial quinazolinediones and their cytotoxicity against mcf-7

HIGHLIGHTS

• who: Sitthivut Charoensutthivarakul and collaborators from the Faculty of Science, Mahidol University, Bangkok, Thailand have published the Article: Rational Design and Lead Optimisation of Potent Antimalarial Quinazolinediones and Their Cytotoxicity against MCF-7, in the Journal: Molecules 2023, 28, x FOR PEER REVIEW Molecules 2023, 28, 2999 of 28/02/2023
• what: The initial SAR study focused on the replacement of the valine linker moiety; according to the in silico prediction using SwissADME concise four-step syntheses toward compounds 4-10 were developed. In this paper, the proof-of-concept lead optimization wa tablished using . . .
  

   

  

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