Rational development of live-attenuated zika virus vaccines

HIGHLIGHTS

  • who: Awadalkareem Adam and collaborators from the Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA have published the article: Rational Development of Live-Attenuated Zika Virus Vaccines, in the Journal: Pathogens 2023, 12, 194. of /2023/
  • how: The chimeric ZIKV vaccine that uses a JEV LAV (SA14-14-2) as the backbone but replaces it vaccine was tested in mice and rhesus macaque models and was found to protect the host with prM-E geneslethal from those of ZIKV.

SUMMARY

    Domain III within the E protein . . .

     

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