HIGHLIGHTS
- who: Juan Liu from the (UNIVERSITY) have published the research work: RBP-RNA interactions in the control of autoimmunity and autoinflammation, in the Journal: (JOURNAL) of 11/09/2022
- what: The authors show that the lncRNA lnc-DC controls human DC differentiation and function via directly binding to signal transducer and activator of transcription 3 (STAT3) in the cytoplasm to promote STAT3 phosphorylation . The study shows that Mettl3 can enhance the mRNA translation of TLR4 signaling adaptor TIRAP and costimulatory molecules CD40 and CD80 in DCs, contributing to DC maturation and activation.169 CCR7 ligation . . .
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