Reaction-based fluorogenic probes for detecting protein cysteine oxidation in living cells

HIGHLIGHTS

• who: Renan B. Ferreira from the (UNIVERSITY) have published the Article: Reaction-based fluorogenic probes for detecting protein cysteine oxidation in living cells, in the Journal: (JOURNAL)
• what: The authors develop a highthroughput assay for measuring S-sulfenation in cells and use it to screen a curated kinase inhibitor library. Fundamentally, the study shows that kinase inhibition by smallmolecules alters cysteine S-sulfenation in cells. While this issue did not hinder application of CysOx probes in the present work, attempts to further miniaturize the cell-based assay to a 384-well plate format were unsuccessful . . .
  

   

  

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