Reactive nitrogen species is required for the activation of the amp-activated protein kinase by statin in vivo*

HIGHLIGHTS

• who: Hyoung Chul Choi from the EXPERIMENTAL PROCEDURES Animals-Male eNOS knock-out (eNOS⫺/⫺) and their littermates, C , mice, weeks of age, were obtained from the Jackson Laboratory (Bar Harbor, ME)Mice were housed in temperature-controlled cages with a, h light-dark cycle and given free access to water and normal chows. These mice were randomly divided into control and statin-treated groups. Mice were abdominally injected with statin (, mg/kg) for , h, and the control mice received a, .9% physiological saline injection. The mice were euthanized with inhaled isoflurane. Mouse hearts, kidneys, livers, and aorta . . .
  

   

  

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