Reactive oxygen species facilitate adipocyte differentiation by accelerating mitotic clonal expansion*

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• who: Haemi Lee from the Haemi Lee, Yoo Jeong Lee, Hyeonjin Choi, Eun Hee Ko, and Jae-woo Kim, From the Department of Biochemistry and Molecular Biology, Center for Chronic Metabolic Disease Research, Institute of Genetic Science, Yonsei University College of Medicine, Brain Korea , Project for Medical Science, Yonsei University, Seoul, Korea Growth-arrested , preadipocytes rapidly express CCAAT/enhancer-binding protein-u2424 (C/EBPu2424) upon hormonal induction of differentiationHowever, the DNA binding activity of C/EBPu2424 is not activated until the cells synchronously reenter S phase during the mitotic clonal expansion (MCE) phase of differentiation. In this . . .
  

   

  

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