Rearrangements in thyroid hormone receptor charge clusters that stabilizebound 3,5⠲,5-triiodo-l-thyronine and inhibit homodimerformation*

HIGHLIGHTS

• who: Marie Togashi from the (UNIVERSITY) have published the paper: Rearrangements in Thyroid Hormone Receptor Charge Clusters That StabilizeBound 3,5⠲,5-Triiodo-L-thyronine and Inhibit HomodimerFormation*, in the Journal: (JOURNAL) of February/11,/2005
• what: The authors utilized targeted mutagenesis to explore elements of the TR that are specifically required for homodimer formation on TREs and tested the hypothesis that the same elements are involved in coupling T3 binding to inhibition of DNA binding. The authors report that these RTH mutations affect clusters of charged amino_acids in the LBD with potential for electrostatic . . .
  

   

  

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