HIGHLIGHTS
- who: Nigel Stallard from the (UNIVERSITY) have published the research: Recent advances in methodology for clinical trials in small populations: the InSPiRe project, in the Journal: (JOURNAL)
- what: The aim of this paper is to summarize the main results of the InSPiRe project. The review discusses these in detail, classifying them according to the type of study design and gain function proposed . The authors have considered designs where subgroups are defined based on a continuous biomarker and several thresholds are considered to define the subgroup. The authors propose improved hypotheses testing approaches based on regression . . .
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