HIGHLIGHTS
SUMMARY
To date, autologous bone grafting (Dimitriou et_al, 2011; Lanza et_al, 2014) is the gold standard technique for bone reconstruction, as it is induced by a non-immunogenic way, the properties required for bone regeneration. Ectopic bone formation was investigated in six studies using subcutaneous implantation in the back of animals or by muscular implantation (e_g, leg muscles). No chemical modification was reported for compositions using both polysaccharides (Fricain et_al, 2013; Schlaubitz et_al, 2014; Frasca et_al, 2017; Ribot et_al, 2017; Fricain et_al, 2018; Maurel et_al, 2021). Interestingly, no chemical modification of pullulan/dextranbased matrix was . . .
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