HIGHLIGHTS
SUMMARY
The ultimate one is the role of resident macrophages and monocyte-derived macrophages in acute gout. Although a sparse number of macrophages phenotypically representative of resident macrophages were present in the synovial fluid, they do not truly characterize the function of synovial resident macrophages, either. What really makes the theory that resident macrophages initiate and drive MSU crystal-induced arthritis challenged is that multiple studies have indicated the synovial lining macrophages display an immune regulatory phenotype and effect. The latter evidence leads the authors to wonder whether synovial resident macrophages actually initiate and drive . . .
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