HIGHLIGHTS
- who: PZM et al. from the (CNR), Italy Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, Semmelweis University have published the paper: Recent Molecular Insights into Agonist-speci fi c Binding to the Mu-Opioid Receptor, in the Journal: (JOURNAL)
SUMMARY
Growing data support that the rate of opioid side-effects including analgesic tolerance development strongly correlates with the pharmacodynamic properties of opioid ligands. Opioids with different efficacies distinctly induce molecular mechanisms related to tolerance, namely receptor phosphorylation and endocytosis, as the basis of G-protein coupled µ-opioid receptor (µOR) desensitization (Williams et_al . . .
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