Receptor activity-modifying protein 1 determines the species selectivity of non-peptide cgrp receptor antagonists*210

HIGHLIGHTS

• who: John J. Mallee from the (UNIVERSITY) have published the research: Receptor Activity-modifying Protein 1 Determines the Species Selectivity of Non-peptide CGRP Receptor Antagonists*210, in the Journal: (JOURNAL) of February/11,/2002
• what: In this report, the authors demonstrate that the small_molecule antagonists, BIBN4096BS, Compound 1, and an analog, Compound 2, have different affinities for the human and rat receptors, and these differences are determined by the species origin of RAMP1 that is co-expressed with CRLR. The results of this investigation demonstrated that the pharmacology was directed exclusively by RAMP1. This . . .
  

   

  

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