HIGHLIGHTS
- who: Top from the Divisions of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan have published the research: Receptor ligand-triggered resistance to alectinib and its, in the Journal: (JOURNAL)
- what: The authors examined whether receptor ligands would trigger resistance to a highly selective ALK-TKI, alectinib.
SUMMARY
Since the authors previously demonstrated that the Hsp90 inhibitor overcame EGFRTKI resistance triggered by HGF, a ligand of MET, in EGFR-mutant lung cancer cells, the authors determined whether Hsp90 inhibition by 17-DMAG would overcome ligand-triggered alectinib resistance in ALK . . .
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