Recognition of sulfonylurea receptor (abcc8/9) ligands by the multidrug resistance transporter p-glycoprotein (abcb1)

HIGHLIGHTS

  • who: Anis Bessadok from the (UNIVERSITY) have published the article: Recognition of Sulfonylurea Receptor (ABCC8/9) Ligands by the Multidrug Resistance Transporter P-glycoprotein (ABCB1), in the Journal: (JOURNAL) of June/24,/2010
  • how: The authors used structural models derived from comparative modeling because they offer the advantage in contrast to crystallographic structures of allowing interpretation of a huge amount of binding data and addressing the multispecific character of these ABC proteins. Experimental Assay Validation Throughout this work the ATPase activity of P-gp-enriched vesicles was used as a reporter of the function of . . .

     

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