HIGHLIGHTS
SUMMARY
In a phylogenetic tree, the root is usually unknown, the observed sequences are usually represented only in the leaves, and the inner nodes represent the relationships among sequences. Conversely, in a B cell lineage tree, the root, the BCR IGH sequence of the unmutated B cell giving rise to the lineage, can be deduced by aligning the IG variable region sequences with sequences stored in a reference database. Approach ClonalTree reconstructs B cell lineage trees based on the minimum spanning tree (MST) and cellular (genotypes) abundances. Minimum spanning tree Given a connected undirected graph . . .
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