Reconstruction of ancestral metabolic enzymes reveals molecular mechanisms underlying evolutionary innovation through gene duplication

HIGHLIGHTS

  • who: Karin Voordeckers and colleagues from the VIB Laboratory for Systems, CMPG Laboratory for Genetics and Genomics, Fathom Information Design, Boston, Massachusetts, United States of America, Faculty of Arts and Sciences Center for Systems, Harvard University, Cambridge, Massachusetts, United States have published the article: Reconstruction of Ancestral Metabolic Enzymes Reveals Molecular Mechanisms Underlying Evolutionary Innovation through Gene Duplication, in the Journal: (JOURNAL) of December/11,/2012
  • what: By resurrecting the ancient genes and proteins using high-confidence predictions from many fungal genome sequences available, the authors show that the very first preduplication enzyme was promiscuous . . .

     

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